Major Shareholders // Chi-Med

Chi-Med has issued a total of 710,785,545 ordinary shares. Each Nasdaq-listed American Depositary Share (ADS) equates to five ordinary shares.

For illustrative purposes only, if converted in their entirety, this would be equivalent to 142,157,109 Nasdaq-traded ADSs.

Insofar as Chi-Med is aware, approximately 49% of the issued share capital of Chi-Med is not in public hands. Such percentage comprises the shares held by Directors and Hutchison Healthcare Holdings Limited, a significant shareholder of Chi-Med.

The tables below show major interests in shares of the Company, notified to the Company under the provisions of rule 5 of the Disclosure Rules and Transparency Rules of the U.K. Financial Conduct Authority, which have been incorporated by reference into the Company's Articles of Association.

Last updated: Sep 24, 2020

Shareholder	Number of Ordinary Shares held	Number of American Depositary Shares Held	Approximate % of Issued Share Capital
Hutchison Healthcare Holdings Limited⁽¹⁾	332,478,770		46.78%
The Capital Group Companies, Inc.	2,651,060	6,183,155	4.72%
Prudential plc group	10,899,950	4,485,069	4.69%
Mitsui & Co., Ltd.	20,742,325		2.92%
General Atlantic Singapore HCM Pte. Ltd.	20,000,000⁽²⁾		2.81%

Note:
(1) Hutchison Healthcare Holdings Limited is a private company registered in the British Virgin Islands and carries on business as a holding company. Hutchison Healthcare Holdings Limited is an indirect wholly-owned subsidiary of CK Hutchison Holdings Limited, which is a Cayman Islands company registered and listed in Hong Kong.
(2) General Atlantic is entitled to further subscribe for up to 16,666,670 ordinary shares by exercising a warrant, in part or whole, at any time after July 2, 2020 and ending on January 3, 2022

Director	Number of Ordinary Shares held	Number of American Depositary Shares Held	Approximate % of Issued Share Capital
Christian Hogg	10,938,020	68,035	1.59%
Johnny Cheng	2,561,460	14,401	0.37%
Simon To	1,800,000	133,237	0.35%
Edith Shih	700,000	100,000	0.17%
Weiguo Su		71,661	0.05%
Dan Eldar	19,000	8,993	0.009%
Tony Mok		10,002	0.007%
Paul Carter	35,240		0.005%
Karen Ferrante		5,785	0.004%
Graeme Jack		3,000	0.002%

Note: "Held" means any legal or beneficial interest held, whether directly or indirectly, on the account of the Director and such Director's "persons closely associated" (as defined in article 3 of the EU Market Abuse Regulation (No 596/2014)).

Significant Shareholders

Directors