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…access to treatment options. [4] Xu J, Shen L, Zhou Z, et al. Surufatinib in advanced extrapancreatic neuroendocrine tumours (SANET-ep): a randomised, double-blind, placebo-controlled, phase 3 study [published online ahead…

…placebo-controlled, phase 3 study [published online ahead of print, 2020 Sep 20]. Lancet Oncol. 2020; S1470-2045(20)30496-4. DOI: 10.1016/S1470-2045(20)30496-4. [5] Xu J, Shen L, Bai C, et al. Surufatinib in advanced…

…line with guidance Group revenue up 12% to $241.2 million (2016: $216.1m); Net loss attributable to Chi-Med $26.7 million (2016: Net profit $11.7m), including $88.0 million in research and development…

…$126.6 million (H1 2016: $104.5m). Net income attributable to Chi-Med of $1.7 million (H1 2016: $0.5m), including $37.5 million in research and development expenses on an as adjusted basis (H1…

…in May 2020 and subsequent grant of Priority Review status in July 2020. Surufatinib – Two NDAs with first China launch in NET planned for late 2020: Progressed non-pancreatic NET…

…and immune evasion. Five other sulfatinib clinical trials are underway in China and the U.S., including two Phase III studies in NET patients (SANET-p and SANET-ep), one Phase II study…

…Society for Medical Oncology Congress (“ESMO”) (Abstract Number 1156O). This is the second NDA acceptance for surufatinib. The first NDA for non-pancreatic NET was accepted by the NMPA in November…

…Hutchison China MediTech Limited (“Chi-Med”) Reports Final Results for the Year Ended December 31 , 2016 and Updates Shareholders on Key Clinical Programs Group: Record revenue, net income and…

…another two NDA3 submissions are imminent, one with savolitinib in lung cancer and a second with surufatinib in pancreatic NET, with launches anticipated for 2021.” “Based on extensive clinical data,…

…(2017: $241.2m). N et loss attributable to Chi‑Med of $74.8 million (2017: net loss $26.7m). Adjusted Group net cash flow (non-GAAP) was -$57.3 million in 2018. Cash from our Commercial…

…Chairman, Chi-Med. “All major clinical readouts in the first half were encouraging, with the stand-out results being surufatinib’s positive Phase III outcome in non-pancreatic NET and savolitinib’s preliminary data in…

…104% to $178.2 million (2014: $87.3m). Net profit from operations attributable to Chi-Med of $8.0 million (2014: net loss -$7.3m), including our booking of $3.1 million in one-time preparation costs…

…that the completed SANET-ep (non-pancreatic NET) and SANET-p (pancreatic NET) studies, along with existing data from surufatinib in U.S. non-pancreatic and pancreatic NET patients, could form the basis to support…

…tumours. A U.S. Phase II study in NET is expected to be initiated based on the conclusion of this Phase I dose escalation study. Sulfatinib is an oral drug candidate…

…to $ 8 2 .3 million ( H1 201 5: $55.6m); Total sales of non-consolidated joint ventures up 9% to $249.6 million (H1 2015: $229.8m); Total net income attributable to…

…SANET-p (pancreatic NET) studies, along with existing data from surufatinib in U.S. non-pancreatic and pancreatic NET patients, could form the basis to support a U.S. NDA submission. The FDA granted…

…(SANET-ep): a randomised, double-blind, placebo-controlled, phase 3 study [published online ahead of print, 2020 Sep 20]. Lancet Oncol. 2020; S1470-2045(20)30496-4. DOI: 10.1016/S1470-2045(20)30496-4. [3] According to Frost & Sullivan. In 2018,…

…– – Preparations underway for the potential submission of surufatinib New Drug Application (“NDA”) by year end 2019 for non-pancreatic NET tumors in China – – Treatment options are limited…

…NET was accepted for review by the NMPA, and the U.S. Food and Drug Administration granted Orphan Drug designation to surufatinib for the treatment of pancreatic NET.   About Surufatinib…

…Chi‑Med of $32.7 million (H1 2017: net profit $1.7m). Cash resources of $416.9 million at Group level as of June 30, 2018 ($479.6m as of December 31, 2017), including cash…

…Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China Session: VPO.CT01 Number: CT142 Link: View Abstract | Download Presentation   Title: Comparison of Pharmacokinetic Profiles and Safety…

…placebo-controlled, multi-centre Phase III sulfatinib registration study to treat pathologically low or intermediate grade NET patients whose disease has progressed, locally advanced or distant metastasised and for whom there is…

…Market under the symbol “HCM.” In addition to the net proceeds which may be generated by the Offering, Chi-Med plans to continue to utilize its various resources, including existing cash…

…price. Chi-Med has applied to have its ADSs approved for listing on the Nasdaq Stock Market under the symbol “HCM.” In addition to the net proceeds which may be generated…

…Raise and Offering do proceed, Chi‑Med intends to use the net proceeds of the potential Equity Raise, together with the cash generated by its operations, primarily to advance the clinical…

…Results (IFRS11) Revenue up 100% to $91.8 million (2013: $46.0m). Net profit attributable to Chi-Med equity holders of $ 5.4 million (2013: $5.9m) as the Company continues to balance a…

…the development of surufatinib, for the treatment of both advanced and progressive pancreatic neuroendocrine tumors (“NET”) and extra-pancreatic (non-pancreatic) NET in patients who are not amenable for surgery. The FDA…

…Department of Gastrointestinal Oncology, The Fifth Medical Center, General Hospital of the PLA Session: Proffered Paper – NETs Abstract Number: 1156O Date & Time: Sunday, September 20, 2020 2:25 PM…

…treatment of non-pancreatic NET. Surufatinib being granted priority review is a positive step forward in potentially bringing this innovative drug to patients, who currently have very limited treatment options.” In…

…and joint ventures (excluding non-consolidated joint ventures) of Chi-Med. OVERALL GROUP: Group revenue of $204.9 million (2018: $214.1m). Net loss attributable to Chi-Med of $106.0 million (2018: net loss of…

…progressing well – evidence of the strength and adaptability of our Commercial Platform to enter new therapeutic areas in future, including oncology and immunology. New factories: Coming online at the…

…as detailed below:   2018 Previous Guidance 2018 Current Guidance Adjustment Group Level: · Consolidated revenue $155-175m $155-175m None · Admin., interest & tax $(16)-(18)m $(16)-(18)m None · Net loss[1]…

…in proof-of-concept clinical trials in the U.S. and several proof-of-concept and late-stage clinical trials in China. Pancreatic NET in China: In 2016, we initiated the SANET-p study, which is a…

…This study follows several trials that are underway in China, including two Phase III studies in pancreatic and non-pancreatic NET that commenced after positive results from a Phase II study,…

…tumors (“NET”) Authors: A Dasari, D Li, MW Sung, C Tucci, JS Kauh, MK Kania, AS Paulson Abstract Link: 4610 Preliminary data from the two NET cohorts in the ongoing…

…sulfatinib monotherapy in patients with advanced grade 1 or 2 advanced NET. 81 patients (41 pancreatic NET and 40 extra-pancreatic NET) were enrolled between November 2014 and January 2016, in…

…NET was accepted for review by the China National Medical Products Administration (NMPA) on November 11, 2019.   About FDA Orphan Drug Designation The FDA Orphan Drug Designation Program provides…

…of surufatinib in NET in China, and the ongoing multi-cohort Phase Ib study in the U.S. (clinicaltrials.gov identifier: NCT02549937). In the U.S., surufatinib was granted Fast Track Designations for development…

…grade advanced NET whose disease has progressed, locally advanced or distant metastasized and for whom there is no effective therapy. Patients are randomized at a 2:1 ratio to receive either…

…September 29. Safety and tolerability data presented from an ongoing U.S. Phase Ib study of surufatinib in pancreatic NET patients who have progressed on Sutent® or Afinitor® treatment will also…

…objective response rate among the 18 efficacy-evaluable NET patients was 44.4% and disease control rate was 100%. By comparison, sunitinib and everolimus, the two approved single agent therapies for neuroendocrine…

…and Cancer Therapeutics in early November 2015 (www.chi-med.com/sulfatinib-ph1-eortc-2015/). The Phase I clinical data indicates that sulfatinib has a superior ORR in NET patients. An ORR of 44% was observed for…

…the potential approval and launch of surufatinib in China, an important development for NET patients with limited treatment options. In order to maximize patient access to surufatinib upon regulatory approval,…

…to see if the firm is authorized by FCA. Report the call to the FCA by calling the FCA Consumer Helpline on 0800 111 6768 or complete the online boiler…

…Resistance Be MET or Will We Not MEK It? Session Type: Clinical Trials Plenary Session Session # & Link: CTPL02 Date & Time: Sunday, March 31: 3:00 PM-5:15 PM Location:…

…What does a depositary do? How does it work in practice? How can I buy an ADR or a DI? Can holders of DIs invest in Chi-Med’s ADRs? Can holders…

…— Analyst – Buy Side Analyst – Sell Side Broker Financial Consultant Fund Manager Investment Banker Institutional Investor Private Investor Shareholder Broadcasting Daily /Newspaper Magazine Online Wire Agency Others Enter…

…Gastrointestinal (Colorectal) Cancer Abstract No. & Link: #3537; abstracts.asco.org/214/AbstView_214_215579.html Poster Link [i]: 16ealJfSDOCUUwuY6Icm22   In FRESCO, fruquintinib demonstrated a statistically significant and clinically meaningful benefit in third-line metastatic CRC patients…

…Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China Session: VPO.CT01 Number: CT142 Link: View Abstract Presenter/Authors Ming Lu, Yanshuo Cao,…

…be very suitable for possible combinations with other immunotherapies. A New Drug Application (“NDA”) for surufatinib for the treatment of patients with advanced non-pancreatic NET was accepted for review by…

…of patients with advanced non-pancreatic NET was accepted for review by the China National Medical Products Administration (“NMPA”) and granted Priority Review status in December 2019. A second NDA for…

…tumours (NETs). Eight NET patients (5 in 300mg QD and 3 in 350mg QD cohort) had confirmed partial response (PR) with median duration of response (DoR) of 13.8 months. The…

…this year in non-pancreatic NET. Our first NDA for surufatinib was granted Priority Review following our submission in late 2019, and preparation for a second NDA in pancreatic NET is…

…Hutchison China MediTech Limited 2019. All rights reserved. Your privacy is important to us. This notice explains our online information practices and the choices you can make about…

…Funding: Hutchison MediPharma. Trial Registration: ClinicalTrials.gov Identifier: NCT02588170.   Citations and Links Please follow the link below to access the publication: Lancet Oncol. 2020;S1470-2045(20)30496-4. [published online ahead of print, 2020…

…patient population. Funding: Hutchison MediPharma. Trial Registration: ClinicalTrials.gov Identifier: NCT02589821.   Citations and Links Please follow the link below to access the publication: Lancet Oncol. 2020; S1470-2045(20)30493-9. [published online ahead…

…to savolitinib than a classification based on pathology. These findings justify investigating savolitinib in MET-driven PRCC. Citations and Links Please follow the DOI link to access the publication: J Clin…

…an acceptable safety profile. Citations and Links Please follow the DOI link to access the publication: J Clin Oncol.2018 Mar 12:JCO2017767145 DOI link: 10.1200/JCO.2017.76.7145 PubMed unique Identifier link: 29528793…

…Article 49(2)(a) to (d) (high net worth companies, unincorporated associations etc) of the Order; or (iv) any other person to whom it may lawfully be communicated (all such persons in…

…(high net worth companies, unincorporated associations etc) of the Order; or (iv) any other person to whom it may lawfully be communicated (all such persons in (i) to (iv) together…

…(d) (high net worth companies, unincorporated associations etc) of the Order; or (iv) any other person to whom it may lawfully be communicated (all such persons in (i) to (iv)…

…October 30, 2017. The net proceeds from the Offering are expected to be used to fund the on-going research and development of the Chi-Med Innovation Platform drug pipeline and for…

…Although the final structure and size of the potential Offering is yet to be determined, Chi-Med expects that the net proceeds from any primary sale of Shares in the Offering,…

…cohort, 1 liver neuroendocrine tumour (NET) and 1 NET with unknown primary site in 300mg cohort, and 1 lymph node NET in 350mg cohort. ORR is 30% among the 13…

…surufatinib and savolitinib.” Simon To, Chairman, Mar 3, 2020 Read More FY2019 Financial Summary Group US$ Revenue $204.9m Net income/(loss) ($106.0m) — Innovation Platform Revenue $16.0m Net income/(loss) ($133.2m) —…

…statements reflect Chi-Med’s current expectations regarding future events, including its expectations regarding the NDA approval and launch of surufatinib for the treatment of patients with pancreatic or non-pancreatic NET in…

…outside of China. Trial Registration ClinicalTrials.gov Identifier: NCT02314819   Citations and Links Please follow the link below to access the publication: JAMA. 2018;319(24):2486-2496. DOI: 10.1001/jama.2018.7855 Link to article: https://jamanetwork.com/journals/jama/article-abstract/2685988…

…on a previous EGFR TKI. This combination might be a potential treatment option for patients with MET-driven resistance to EGFR TKIs.   Citations and Links Please follow the link below…

…Han, Center for Lung Cancer, National Cancer Center, Goyang, Republic of Korea Session: FP14 – Targeted Therapy – Clinically Focused Abstract # / Link: #FP14.03 / Link Availability Date: Thursday,…

…be sold nor may offers to buy be accepted prior to the time the Form F-1 Registration Statement becomes effective. The Form F-1 Registration Statement and all subsequent amendments may…

…but has not yet become effective. The ADSs may not be sold, nor may offers to buy be accepted, prior to the time the Registration Statement becomes effective. The Registration…

…Markets Act 2000 (Financial Promotion) Order 2005 (the “Order”) or (iii) persons falling within Article 49(2)(a) to (d) (high net worth companies, unincorporated associations etc.) of the Order; or (iv)…

…(d) (high net worth companies, unincorporated associations etc) of the Order; or (iv) any other person to whom it may lawfully be communicated (all such persons in (i) to (iv)…

…who fall within Article 49(2)(a) to (d) (high net worth companies, unincorporated associations etc) of the Order; or (iv) any other person to whom it may lawfully be communicated (all…

…net worth companies, unincorporated associations etc) of the Order; or (iv) any other person to whom it may lawfully be communicated (all such persons in (i) to (iv) together being…

…The net proceeds from the Offering are expected to be used to fund the on-going research and development of the Chi-Med Innovation Platform drug pipeline and for working capital and…

…Act 2000 (Financial Promotion) Order 2005, or the Order, (ii) high net worth entities, and other persons to whom it may lawfully be communicated, falling within Article 49(2)(a) to (d)…

…Services and Markets Act 2000 (Financial Promotion) Order 2005, or the Order, (ii) high net worth entities, and other persons to whom it may lawfully be communicated, falling within Article…

…19(5) of the Financial Services and Markets Act 2000 (Financial Promotion) Order 2005, or the Order, (ii) high net worth entities, and other persons to whom it may lawfully be…

…“Order”) or (iii) are persons falling within Article 49(2)(a) to (d) (high net worth companies, unincorporated associations etc.) of the Order; or (iv) are persons to whom an invitation or…

…Cinney Zhang czhang429@bloomberg.net Sam Fazeli mfazeli@bloomberg.net…

…discounts and commissions. The Offering is expected to close on January 27, 2020, subject to customary closing conditions. Chi-Med will receive all of the net proceeds from the sale of…

…BofA MERRILL LYNCH Dr. Alec W. Stranahan+1 646 743 2109 alec.stranahan@bofa.com Dr. Geoff Meacham+1 646 855 1004 geoff.meacham@bofa.com BLOOMBERG Cinney Zhangczhang429@bloomberg.net Sam Fazelimfazeli@bloomberg.net CANACCORD GENUITY Dr. John Newman+1…

…for the Offering has not yet been determined. Chi-Med will receive all of the net proceeds from the sale of ADSs in the Offering, if completed, which it intends to…

…underway in China and the United States, including two Phase III studies and one Phase II study in NET patients (SANET-p, SANET-ep and SANET-1), one Phase II study in thyroid…

…SANET-p trial is a randomized, double-blind, placebo-controlled, multi-center, Phase III pivotal registration trial to treat about 190 pathologically low or intermediate grade pancreatic NET patients in China whose disease has…

…Form accelerate Strategy for product registration Qualifications Bachelor degree and above in Pharmacy or Pharmaceutical 5 years or more drug registration experience in pharmaceutical industry Prefer oncology drug registration background…

…Pharmacy, Clinical pharmacology or public health and 5 years industry or relevant experience, OR Advanced degree, e.g. PhD, PharmD and 2 years industry experience Experience with US and EU CMC…

…project. Review monitoring reports. Check TMF before archiving. Qualifications At least bachelor degree in pharmacy, biochemistry or related major. Mater degree is preferred. At least 3 years industry experience with…

…  Citations Journal: Clinical Cancer Research June 15, 2019 (25) (12) 3486-3494 (Published Online First March 4, 2019) DOI: 10.1158/1078-0432.CCR-18-2994 PubMed: 30833272   Abstract Purpose: No anti-angiogenic treatment is yet…

…infant formula is sold in China through an online retailer and specialty retail outlets. Hutchison Healthcare Our wholly owned subsidiary and is primarily engaged in the manufacture, marketing and distribution…

…Hall A, Poster Board: #30 Session: Gastrointestinal (Colorectal) Cancer Abstract No. & Link: #3537; abstracts.asco.org/214/AbstView_214_215579.html Copies of this poster may be obtained from the American Society of Clinical Oncology….

…other limits or discretions should be identified and explained at the time of approving the policy; 10.3.5. proportionality – the link between individual awards, the delivery of strategy and the…

…Live virtual investor conference. An on-demand archive is available for 90 days. TIME: 9.00am Eastern Standard Time LINK: www.adr.db.com/dbvic…

…Live virtual investor conference. An on-demand archive is available for 90 days. TIME: 9am Eastern Standard Time LINK: www.adr.db.com/dbvic…

…The Royal Society of Medicine, London, UK Please visit rsm.ac.uk for more information. A video recording of the 20-minute presentation is available. RSM video link Note: there is…

…  Live virtual investor conference. TIME: 9:30am Eastern Daylight Time LINK: www.adr.db.com/dbvic…

…which is listed on The Stock Exchange of Hong Kong. The CKHH tax strategy for the CKHH Group can be found on the website of CKHH via the link here….

…Session: Gastrointestinal (Colorectal) Cancer Abstract No. & Link: #3544; abstracts.asco.org/214/AbstView_214_224293.html Copies of this poster can be obtained from American Society of Clinical Oncology and the author of the poster….

Press Release Group | 15 Apr 2019 Chi-Med Files Application to List in Hong Kong and Announces Proposed Global Offering Listing Documents Redacted form of the draft…